This calculator is helpful.
http://circuitwizard.bluesea.com/
10% max drop at expected load. Don't forget to include all wiring in the circuit. Neg and positive. For Critical items, like fridges, sensitive electronics, charger feeds etc, aim for 3% or less. Remember that the wire is only part of the equation, so every fuse, terminal, and splice adds some voltage drop. So I try to aim for 2% in the wiring for things like DC fridges, and chargers. Things like LED lights, water pumps, USB chargers, etc are fine with 10%, but I usually aim for 7% or less.
The fuse size is determind by two factors. The max fuse size is determined by the smallest wire protected by that circuit. Wire has insulation with a temp limit, usually 75C or 90C. Then using the gauge to determine ampacity for that wire. This is the current limit for the wire, before the insulation will overheat and fail. For 10 gauge with 90C insulation, that is 40A. The minimum size for a fuse is the limit at which it will nuisance trip. For example a fridge only uses 4-5A continuous, but it will surge briefly at startup. So a 15A fuse is normally suggested. It is good to go larger than the minimum size, as this will reduce the voltage drop across the fuse while still protecting the wire.